Treatment of chronic rhinosinusitis using erythromycin phonophoresis.

Abstract

Bacterial biofilms have been implicated in many chronic infective diseases, including chronic rhinosinusitis (CRS). Therapeutic ultrasound enhances the breakdown of bacterial biofilms and is clinically effective in CRS treatment, while phonophoresis has also been utilized for antibiotic delivery through the skin. The objective of this case report is to describe the results of a novel treatment, erythromycin phonophoresis, in a woman with CRS. A 31-year-old woman with a 7-month history of CRS refractory to conventional medical management was treated with erythromycin phonophoresis to both maxillary sinuses. Individual sinus symptom severity was assessed and sinus CT scans were obtained both pretreatment and posttreatment. After treatment, the total sinusitis symptom score improved from 12 to 0 and the CT scan showed almost complete disease resolution. At 5-month follow-up, the patient reported sustained improvement. Erythromycin phonophoresis has potential as an effective treatment for CRS.

• Authors: Noureddin Nakhostin Ansari, Mojtaba Fathali, Soofia Naghdi, Jim Bartley, Mohammad Saeed Rastak
• Journal: Physiotherapy theory and practice (Physiother Theory Pract) Vol. 29 Issue 2 Pg. 159-65 (Feb 2013) ISSN: 1532-5040 [Electronic] England
• PMID: 22891948 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Erythromycin

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage)
• Biofilms (drug effects)
• Chronic Disease
• Disability Evaluation
• Erythromycin (administration & dosage)
• Female
• Humans
• Maxillary Sinusitis (diagnosis, drug therapy, microbiology)
• Phonophoresis
• Rhinitis (diagnosis, drug therapy, microbiology)
• Severity of Illness Index
• Tomography, X-Ray Computed
• Treatment Outcome