Abstract | BACKGROUND: METHODS: RESULTS: In the FLEEOX group, the clinical response rate (RR) of chemotherapy was 85.4% (41 of 48 patients) and the median survival time was 25 months. The 1-year and 2-year disease-free survival (DFS) rates were 85.4% and 45.8%, respectively. In the XELOX group, the clinical RR was 59.5% and the median survival time was 9 months, while the 1-year and 2-year survival rates were 35.2% and 8.3%, respectively. The clinical RR, the R0 resection rate, the median survival time, and the 1-year and 2-year DFS rates were significantly better (P < 0.05) in the FLEEOX group than in the XELOX group. In addition, there were no significant differences in the rates of toxic and adverse reactions or post-operative complications between the two groups. CONCLUSIONS: For patients with a preoperative diagnosis of unresectable gastric cancer, the efficacy of the FLEEOX regimen, which combines arterial with venous administration, was better than that of the XELOX regimen, using venous administration only. This combination of arterial and venous administration could be useful for improving the efficacy of neoadjuvant chemotherapy for gastric cancer.
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Authors | Caihua Zhang, Guoli Li, Chaogang Fan, Jian Xu, Jianmin Cao, Shen Liu, Ning Li |
Journal | World journal of surgical oncology
(World J Surg Oncol)
Vol. 10
Pg. 162
(Aug 14 2012)
ISSN: 1477-7819 [Electronic] England |
PMID | 22891660
(Publication Type: Journal Article)
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Chemical References |
- Organoplatinum Compounds
- Oxaliplatin
- Epirubicin
- Etoposide
- Leucovorin
- Fluorouracil
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Drug Administration Routes
- Epirubicin
(administration & dosage)
- Etoposide
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Follow-Up Studies
- Humans
- Injections, Intra-Arterial
- Injections, Intravenous
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Organoplatinum Compounds
(administration & dosage)
- Oxaliplatin
- Prognosis
- Stomach Neoplasms
(drug therapy, mortality)
- Survival Rate
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