Abstract | BACKGROUND:
Therapy with tumour necrosis factor α ( TNF) inhibitors can be associated with paradoxical reactions, namely the de novo development or flaring of conditions that usually respond to these therapeutic agents, such as arthritis, inflammatory bowel disease, sarcoidosis or psoriasis. They are considered a class effect of these drugs, and their incidence ranges from 1 to 5%, with paradoxical psoriasis ( psoriasis vulgaris, palmoplantar pustulosis, scalp psoriasis and their combinations) being most frequently reported. Treatment of paradoxical psoriasis often requires withdrawal of the inducing drug and switching to another anti-TNF agent, but often this cannot avoid recurrence or persistence of the rash and/or loss of the therapeutic effect on the underlying condition. CASE REPORT: CONCLUSION: A review of the reported cases suggests that this may be a therapeutic option in patients who develop paradoxical psoriasis while under treatment for arthritis or Crohn's disease.
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Authors | Lluís Puig, Caridad E Morales-Múnera, Anna López-Ferrer, Carme Geli |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 225
Issue 1
Pg. 14-7
( 2012)
ISSN: 1421-9832 [Electronic] Switzerland |
PMID | 22890275
(Publication Type: Case Reports, Journal Article, Review)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Anti-Inflammatory Agents
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Tumor Necrosis Factor-alpha
- Ustekinumab
- Adalimumab
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Topics |
- Adalimumab
- Anti-Inflammatory Agents
(adverse effects)
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(adverse effects)
- Arthritis, Psoriatic
(drug therapy)
- Drug Eruptions
(drug therapy, etiology)
- Female
- Humans
- Middle Aged
- Psoriasis
(chemically induced)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Ustekinumab
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