[Regulation of gluconeogenesis in the liver of vitamin B1-deficient rats].

Abstract

Radiometric assays revealed that thiamine deficiency in rats to whom hydroxythiamine was administered in variable doses, is concomitant with activation of gluconeogenesis from pyruvate in liver tissue. The most probable mechanism of this effect is the cAMP-dependent activation of key enzymes of intracellular glucose synthesis. This process is facilitated by the diminution of the ratio of free forms of NAD+ and NADPH in the cytoplasm.

• Authors: S S Maglysh, Z V Gorbach, O V Konovalenko
• Journal: Biokhimiia (Moscow, Russia) (Biokhimiia) Vol. 55 Issue 8 Pg. 1491-7 (Aug 1990) ISSN: 0320-9725 [Print] Russia (Federation)
• Vernacular Title: Reguliatsiia gliukoneogeneza v pecheni vitamin B1-defitsitnykh krys.
• PMID: 2288988 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lactates
• Liver Glycogen
• Pyruvates
• Aspartate Aminotransferases
• Alanine Transaminase
• Glucose

Topics

• Alanine Transaminase (metabolism)
• Animals
• Aspartate Aminotransferases (metabolism)
• Gluconeogenesis
• Glucose (metabolism)
• Lactates (metabolism)
• Liver (enzymology, metabolism)
• Liver Glycogen (metabolism)
• Male
• Pyruvates (metabolism)
• Rats
• Thiamine Deficiency (metabolism)