In vitro and in vivo antitumor activity of doxorubicin-loaded alginic-acid-based nanoparticles.

Abstract

The antitumor activities of DOX-loaded alginic acid/poly[2-(diethylamino)ethyl methacrylate] (ALG-PDEA) nanoparticles are evaluated both in vitro and in vivo. TEM imaging shows that the ALG-PDEA NPs have a spherical morphology with a size of about 120 nm. CLSM observations reveal that the negatively charged ALG-PDEA NPs can be taken up well by cells. In vivo NIR fluorescence imaging shows that the ALG-PDEA NPs can passively target the tumor area because of the EPR effect in the H22 tumor-bearing mouse. In vivo antitumor efficacy examinations indicate that DOX-loaded ALG-PDEA NPs have significantly superior efficacy in impeding tumor growth compared to free DOX and low toxicity to living mice.

• Authors: Yuan Cheng, Shuling Yu, Jingjing Wang, Hanqing Qian, Wei Wu, Xiqun Jiang
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 12 Issue 10 Pg. 1326-35 (Oct 2012) ISSN: 1616-5195 [Electronic] Germany
• PMID: 22887841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Alginates
• Antibiotics, Antineoplastic
• Drug Carriers
• Fluorescent Dyes
• Polymethacrylic Acids
• alginic acid-poly(2-(diethylamino)ethyl methacrylate)
• Doxorubicin

Topics

• Alginates
• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics, pharmacology)
• Biological Transport
• Cell Line, Tumor
• Cell Survival (drug effects)
• Doxorubicin (administration & dosage, pharmacokinetics, pharmacology)
• Drug Carriers
• Drug Compounding
• Fluorescent Dyes
• Liver Neoplasms (drug therapy, pathology)
• Male
• Mice
• Mice, Inbred ICR
• Microscopy, Electron, Transmission
• Microscopy, Fluorescence
• Nanoparticles
• Neoplasm Transplantation
• Optical Imaging
• Particle Size
• Polymethacrylic Acids