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Distribution of human recombinant interferon-alpha 2 in rat plasma, liver, and experimental liver metastases.

Abstract
It has been ascertained that one of several possible reasons for negligible interferon activity in solid tumors, namely, hepatic metastases induced in rats after intraportal injection of Walker carcinoma 256 cells, is the significantly lower levels of interferon in the interstitial fluid of metastases in comparison to normal liver and plasma.
AuthorsV Bocci, F Carraro, A Naldini, P P Cagol, E M Pasqual, C Prevaldi, D Casara
JournalMolecular biotherapy (Mol Biother) Vol. 2 Issue 4 Pg. 233-4 (Dec 1990) ISSN: 0952-8172 [Print] United States
PMID2288723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
Topics
  • Animals
  • Humans
  • Interferon alpha-2
  • Interferon-alpha (blood, metabolism)
  • Liver Neoplasms (metabolism, secondary)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins (metabolism)

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