[Impact of Down syndrome on the surgical treatment of congenital heart defects].

Abstract

OBJECTIVE:

To evaluate the impact of Down syndrome (DS) on surgical management in patients with congenital heart defects (CHD).

METHODS:

We retrospectively analyzed the clinical data from 35 children with DS and CHD, who underwent cardiac surgery between 2004 and 2009. The data on surgical mortality, complications and follow-up results are emphasized.

RESULTS:

All of the patients underwent primary repair. One child (2.9%) with DS and complete atrioventricular septal defect (CAVSD) died early postoperatively because of pulmonary hypertension. Two patients (5.7%) had low cardiac output syndrome, and 15 (42.9%) suffered pulmonary complications. III degree atrioventricular block (AVB) occurred in 4 patients (11.5%). Thirty children who were followed up 10 months to 6 years [(3.8±1.1) years] are in NYHA class I or II. There were no reoperations or later death.

CONCLUSION:

CHD in DS children can be repaired with a low risk of mortality, although a high incidence of severe infections and III degree AVB can result in a complicated postoperative course. The results of mid-term follow up are satisfactory.

• Authors: Weizhi Zhang, Yifeng Yang, Can Huang, Tianli Zhao
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 37 Issue 7 Pg. 695-8 (Jul 2012) ISSN: 1672-7347 [Print] China
• PMID: 22886226 (Publication Type: English Abstract, Journal Article)

Topics

• Child
• Child, Preschool
• Down Syndrome (complications)
• Female
• Heart Defects, Congenital (complications, mortality, surgery)
• Heart Septal Defects, Ventricular (complications, mortality, surgery)
• Humans
• Infant
• Male
• Postoperative Complications (etiology)
• Retrospective Studies
• Survival Analysis
• Treatment Outcome