HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Thymidylate synthase genetic polymorphisms and cancer risk: a meta-analysis of 37 case-control studies.

AbstractBACKGROUND:
Several studies have evaluated the association between polymorphisms of thymidylate synthase (TS) and cancer risk in diverse populations but with conflicting results. By pooling the relatively small samples in each study, it is possible to evaluate the association using a meta-analysis.
METHODS:
A comprehensive search was conducted to identify all case-control studies on TS on a 28-bp tandem repeats in 5'untranslated region (5'UTR) and a 6-bp insertion (ins) and deletion (del) mutation in 3'UTR of the gene and cancer risk. Meta-analysis was conducted using a fixed and random effect model.
RESULTS:
Our meta-analysis on a total of 13 307 cancer cases and 18 226 control subjects from 37 published case-control studies showed no significant association between the risk of cancer and the 5'UTR 28-bp tandem repeats polymorphism (3R/3R vs. 2R/2R: OR = 1.06, 95%CI, 0.93 - 1.20) or the 3'UTR 6-bp ins/del polymorphism (del6/del6 vs. ins6/ins6: OR = 0.93, 95%CI, 0.81 - 1.08) with significant between-study heterogeneity. In the cancer type- and ethnic subgroup-stratification analyses, we did not find any association between TS polymorphisms and cancer risk either.
CONCLUSION:
TS 5'UTR 28-bp tandem repeats and 3'UTR 6-bp ins/del polymorphisms may not be associated with cancer risk.
AuthorsJian Tang, Pei-Pei Wang, Yan-Yan Zhuang, Wen-Jie Chen, Feng-Ting Huang, Shi-Neng Zhang
JournalChinese medical journal (Chin Med J (Engl)) Vol. 125 Issue 14 Pg. 2582-8 (Jul 2012) ISSN: 2542-5641 [Electronic] China
PMID22882943 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • Thymidylate Synthase
Topics
  • 3' Untranslated Regions (genetics)
  • 5' Untranslated Regions (genetics)
  • Case-Control Studies
  • Genetic Predisposition to Disease (genetics)
  • Humans
  • Neoplasms (epidemiology, genetics)
  • Polymorphism, Genetic (genetics)
  • Tandem Repeat Sequences (genetics)
  • Thymidylate Synthase (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: