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The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.

Abstract
Vineatrol(®) 30 is a grapevine-shoot extract, which contains resveratrol as well as considerable amounts of so-called resveratrol oligomers such as hopeaphenol and r2-viniferin. In this study, we analysed whether the two above-mentioned resveratrol oligomers were able to inhibit the growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82, compared their potency to inhibit tumour cell growth with that of resveratrol and determined whether the induction of apoptosis via caspase 9 and 3/7 activation underlies the tumour cell growth-inhibiting effect of hopeaphenol and r2-viniferin. Vineatrol(®) 30, resveratrol, hopeaphenol and r2-viniferin inhibited the growth of D-GBM and DH82 cells in a concentration-dependent manner, whereby hopeaphenol and r2-viniferin were more potent than resveratrol itself in inhibiting the growth of the canine tumour cell lines. Moreover, the anti-proliferative effect of both resveratrol oligomers in D-GBM cells is based on their capacity to induce caspase 9 and 3/7 activation.
AuthorsM T Empl, S Macke, P Winterhalter, C Puff, S Lapp, G Stoica, W Baumgärtner, P Steinberg
JournalVeterinary and comparative oncology (Vet Comp Oncol) Vol. 12 Issue 2 Pg. 149-59 (Jun 2014) ISSN: 1476-5829 [Electronic] England
PMID22882564 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2012 John Wiley & Sons Ltd.
Chemical References
  • Antineoplastic Agents
  • Phenols
  • Polyphenols
  • Stilbenes
  • hopeaphenol
  • r2-viniferin
  • Resveratrol
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Cell Line, Tumor
  • Dogs
  • Glioblastoma (metabolism)
  • Histiocytic Sarcoma (metabolism)
  • Molecular Structure
  • Phenols
  • Polyphenols (chemistry, pharmacology)
  • Resveratrol
  • Stilbenes (chemistry, pharmacology)

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