Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.

Abstract

The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.

• Authors: Chia-Hsin Huang, Mei-Fen Chen, Hsien-Hui Chung, Juei-Tang Cheng
• Journal: Journal of natural products (J Nat Prod) Vol. 75 Issue 8 Pg. 1465-8 (Aug 24 2012) ISSN: 1520-6025 [Electronic] United States
• PMID: 22880723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzaldehydes
• Blood Glucose
• Hypoglycemic Agents
• Insulin
• syringaldehyde

Topics

• Animals
• Benzaldehydes (pharmacology)
• Blood Glucose (analysis, drug effects)
• Diabetes Mellitus, Experimental (chemically induced, drug therapy)
• Dose-Response Relationship, Drug
• Hibiscus (chemistry)
• Hypoglycemic Agents (chemistry, pharmacology)
• Insulin (metabolism, pharmacology)
• Insulin Resistance (immunology)
• Male
• Molecular Structure
• Plant Stems (chemistry)
• Rats