Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study.

Abstract

PURPOSE:

To assess the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome.

METHODS:

This study evaluated 64 eyes of 32 patients (age: 62.6±12.8 years (mean±SD)) in whom treatment with 0.1% sodium hyaluronate was insufficiently responsive. The eyes were randomly assigned to one of the two regimens in each patient: topical administration of sodium hyaluronate and diquafosol tetrasodium in one eye, and that of sodium hyaluronate in the other. Before treatment, and 2 and 4 weeks after treatment, we determined tear volume, tear film break-up time (BUT), fluorescein and rose bengal vital staining scores, subjective symptoms, and adverse events.

RESULTS:

We found a significant improvement in BUT (P=0.049, Dunnett test), fluorescein and rose bengal staining scores (P=0.02), and in subjective symptoms (P=0.004 for dry eye sensation, P=0.02 for pain, and P=0.02 for foreign body sensation) 4 weeks after treatment in the diquafosol eyes. On the other hand, we found no significant change in these parameters after treatment in the control eyes.

CONCLUSIONS:

In dry eyes, where sodium hyaluronate monotherapy was insufficient, diquafosol tetrasodium was effective in improving objective and subjective symptoms, suggesting its viability as an option for the additive treatment of such eyes.

• Authors: K Kamiya, M Nakanishi, R Ishii, H Kobashi, A Igarashi, N Sato, K Shimizu
• Journal: Eye (London, England) (Eye (Lond)) Vol. 26 Issue 10 Pg. 1363-8 (Oct 2012) ISSN: 1476-5454 [Electronic] England
• PMID: 22878452 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Fluorescent Dyes
• Ophthalmic Solutions
• Polyphosphates
• Purinergic P2Y Receptor Agonists
• Uracil Nucleotides
• Viscosupplements
• Rose Bengal
• diquafosol
• Hyaluronic Acid
• Fluorescein

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Therapy, Combination
• Dry Eye Syndromes (drug therapy, metabolism, physiopathology)
• Female
• Fluorescein (metabolism)
• Fluorescent Dyes (metabolism)
• Humans
• Hyaluronic Acid (administration & dosage, adverse effects)
• Male
• Middle Aged
• Ophthalmic Solutions
• Polyphosphates (administration & dosage, adverse effects)
• Prospective Studies
• Purinergic P2Y Receptor Agonists (administration & dosage, adverse effects)
• Rose Bengal (metabolism)
• Tears (chemistry)
• Uracil Nucleotides (administration & dosage, adverse effects)
• Viscosupplements (administration & dosage, adverse effects)