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Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats.

Abstract
Rare sugar D-psicose has cropped up as a non-toxic and effective compound to protect and preserve pancreatic β-islets in the growing type 2 diabetes mellitus (T2DM) rats through the regulation of glucose and fat metabolism. The present study was undertaken to examine the effect of rare sugar D-psicose on the protection of pancreatic β-islets using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a T2DM model. Treated rats were fed with 5% D-psicose or 5% D-glucose supplemented drinking water, and only water in the control for 13 weeks. A non-diabetic Long-Evans Tokushima Otsuka (LETO), fed with water served as a counter control of OLETF. D-Psicose significantly attenuated progressive β-islet fibrosis and preserved islets, evaluated by hematoxylin-eosin staining, Masson's trichrome staining and immunostainings of insulin and α-smooth muscle actin (SMA). D-Psicose significantly reduced increase in body weight and abdominal fat deposition. Oral glucose tolerance test (OGTT) showed reduced blood glucose levels suggesting the improvement of insulin resistance. All these data suggests that D-psicose protected and preserved pancreatic β-islets through the maintenance of hyperglycemia and by the prevention of fat accumulation in OLETF rats.
AuthorsAkram Hossain, Fuminori Yamaguchi, Toru Matsunaga, Yuko Hirata, Kazuyo Kamitori, Youyi Dong, Li Sui, Ikuko Tsukamoto, Masaki Ueno, Masaaki Tokuda
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 425 Issue 4 Pg. 717-23 (Sep 07 2012) ISSN: 1090-2104 [Electronic] United States
PMID22877751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Actins
  • Adipokines
  • Insulin
  • smooth muscle actin, rat
  • psicose
  • Fructose
  • Glucose
Topics
  • Abdominal Fat (drug effects, pathology)
  • Actins (metabolism)
  • Adipokines (blood)
  • Animals
  • Body Mass Index
  • Body Weight (drug effects)
  • Cytoprotection
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Eating (drug effects)
  • Fibrosis
  • Fructose (administration & dosage)
  • Glucose (metabolism)
  • Glucose Tolerance Test
  • Insulin (metabolism)
  • Insulin Resistance
  • Insulin-Secreting Cells (drug effects, metabolism, pathology)
  • Male
  • Obesity (blood, drug therapy)
  • Rats
  • Rats, Inbred OLETF

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