Anabolic therapies for osteoporosis.

Abstract	As the first FDA-approved anabolic agent for osteoporosis, teriparatide has proven effective for people at highest risk of fracture, despite limitations of expense, route of delivery, and length of treatment. Available data show that combination therapy with teriparatide and antiresorptive agents does not offer a therapeutic advantage. However, treatment with an antiresorptive agent after teriparatide discontinuation is essential to prevent the ensuing bone loss. Although pretreatment with bisphosphonates may somewhat attenuate the anabolic effect of teriparatide, significant gains in bone mineral density are still achieved and prior bisphosphonate use should not dissuade clinicians from using teriparatide in select patients.
Authors	Alexander V Uihlein, Benjamin Z Leder
Journal	Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 41 Issue 3 Pg. 507-25 (Sep 2012) ISSN: 1558-4410 [Electronic] United States
PMID	22877427 (Publication Type: Journal Article, Review)
Copyright	Copyright © 2012 Elsevier Inc. All rights reserved.
Chemical References	Anabolic Agents Bone Density Conservation Agents Drugs, Investigational Glucocorticoids Teriparatide Alendronate
Topics	Alendronate (administration & dosage, adverse effects, pharmacology, therapeutic use) Anabolic Agents (administration & dosage, adverse effects, pharmacology, therapeutic use) Animals Bone Density (drug effects) Bone Density Conservation Agents (administration & dosage, adverse effects, therapeutic use) Bone and Bones (chemistry, drug effects, metabolism) Dose-Response Relationship, Drug Drug Delivery Systems Drug Monitoring Drug Therapy, Combination (adverse effects) Drugs, Investigational (administration & dosage, adverse effects, pharmacology, therapeutic use) Female Glucocorticoids (adverse effects) Humans Male Osteoporosis (complications, drug therapy, metabolism) Osteoporosis, Postmenopausal (complications, drug therapy, metabolism) Osteoporotic Fractures (prevention & control) Osteosarcoma (chemically induced, complications, prevention & control) Teriparatide (adverse effects, therapeutic use)

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