Owing to the intricate and multifaceted pathology of
cerebral stroke, multiple
drug therapy had long been suggested for effective
stroke treatment. Therefore, the development of a potential new combination of
drug is necessitated which can bring about desirable improved neuroprotection targeting different pathways against
ischemic stroke. In this context, we hypothesize the combination effect of
Piroxicam, a Non steroidal anti inflammatory
drug with
Ifenprodil, a NR2b selective NMDAR antagonist in animal model of
cerebral ischemia. A few past studies have enumerated the neuroprotective roles of
Piroxicam and
Ifenprodil administered in singlet against
cerebral ischemia in animal model, hence we hypothesized that by using
Piroxicam and
Ifenprodil in combination would provide additive neuroprotection than either of the agents used alone. In this article, we discuss our hypothesis regarding the possibility of
Piroxicam and
Ifenprodil as a potent combination which may have a positive therapeutic role in treatment of
cerebral ischemia through its anti-inflammatory, anti-apoptotic and anti-oxidative characteristics of
Piroxicam with
Ifenprodil which has been proved to have neuroprotective,
anticonvulsant and antinociceptive effects and has potentials for the treatment of several neuropsychiatric disorders, such as
Parkinson's disease alcoholism and
drug addiction.