HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Benefits of using magnesium sulphate (MgSO₄) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria.

AbstractBACKGROUND:
Despite clear emphasis through the Millennium Development Goals, the problem of high maternal mortality persists especially within low and middle income countries. Various studies report remarkably high maternal mortality rates in northern Nigeria, where maternal mortality rates exceed 1,000 deaths per 100,000 live births and eclampsia contributes approximately 40% of maternal deaths. Across Nigeria, diazepam is routinely used for the management of eclampsia. Prior to February 2008, diazepam was widely used for the management of eclampsia in Kano State (within northern Nigeria) with case fatality rate being over 20%. While magnesium sulphate (MgSO4) is recognized as the most effective drug for the management of eclampsia; this study aims to compare MgSO4 therapy with diazepam therapy in terms of case fatality rates and costs.
FINDINGS:
This retrospective study, including 1045 patients with eclampsia and pre-eclampsia during the years 2008 and 2009, reports a drop in case fatality rates from 20.9% (95% CI: 18.7, 23.2) to 2.3% (95% CI: 1.4, 3.2) among eclampsia patients following the MgSO4 intervention. The study observed no significant difference in the cost of using MgSO4 therapy compared to diazepam therapy.
CONCLUSIONS:
The study found a remarkable reduction in case fatality rate due to eclampsia in those who received MgSO4 therapy with minimal increase in costs when compared to diazepam therapy. Concerted efforts should be focused on properly introducing MgSO4 into emergency obstetric protocols especially within developing countries to reduce maternal mortality and also impact on health system performance.
AuthorsEkechi Okereke, Babatunde Ahonsi, Jamilu Tukur, Salisu Mohammed Ishaku, Ayodeji Babatunde Oginni
JournalBMC research notes (BMC Res Notes) Vol. 5 Pg. 421 (Aug 08 2012) ISSN: 1756-0500 [Electronic] England
PMID22873658 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Magnesium Sulfate
  • Diazepam
Topics
  • Adolescent
  • Adult
  • Developing Countries
  • Diazepam (economics, pharmacology, therapeutic use)
  • Eclampsia (drug therapy, mortality)
  • Female
  • Humans
  • Magnesium Sulfate (economics, pharmacology, therapeutic use)
  • Maternal Mortality
  • Middle Aged
  • Nigeria (epidemiology)
  • Pre-Eclampsia (drug therapy, mortality)
  • Pregnancy
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: