Reappraise the effect of redo-Kasai for recurrent jaundice following Kasai operation for biliary atresia in the era of liver transplantation.

Abstract

PURPOSE:

This study was conducted to reappraise the efficacy of redo-Kasai (or revision) in the era of liver transplantation as a treatment option in those patients with recurrent jaundice after initially successful Kasai procedure.

METHODS:

We studied ten patients that received redo-Kasai, among a total of 102 patients diagnosed with biliary atresia after receiving Kasai operation from 1986 to 2011.

RESULTS:

Kasai operation was done at a median age of 55 days and redo-Kasai at 150 days. The bilirubin levels returned to normal in six patients after the procedure. Four of six enjoyed jaundice-free survival with native liver till the time of last follow-up. Three patients died and three received liver transplantation (LT). Only one out of seven patients with three or more episodes of cholangitis survived with native liver, while all the three patients with 1 or 0 episode survived with native liver. The difference was significant (P = 0.033). Re-do Kasai did not result in more blood loss or operative time during LT.

CONCLUSION:

Redo-Kasai is still valuable in the era of LT and the episodes of cholangitis are the decisive factors affecting the outcome of the procedure.

• Authors: Manuel Mikery Mendoza, Jiun-Hung Chiang, Shin-Yi Lee, Chun-Yu Kao, Jiin-Haur Chuang, Mao-Meng Tiao, Chih-Sung Hsieh
• Journal: Pediatric surgery international (Pediatr Surg Int) Vol. 28 Issue 9 Pg. 861-4 (Sep 2012) ISSN: 1437-9813 [Electronic] Germany
• PMID: 22872304 (Publication Type: Comparative Study, Journal Article)

Topics

• Biliary Atresia (surgery)
• Female
• Follow-Up Studies
• Humans
• Incidence
• Infant
• Infant, Newborn
• Jaundice (epidemiology, etiology)
• Liver Transplantation
• Male
• Operative Time
• Portoenterostomy, Hepatic (methods)
• Prognosis
• Recurrence
• Retrospective Studies
• Taiwan (epidemiology)
• Treatment Outcome