Abstract | BACKGROUND: RESULTS: We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls. CONCLUSION: Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of four weeks preoperative chemotherapy treatment.
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Authors | Jana Schmitt, Christina Backes, Nasenien Nourkami-Tutdibi, Petra Leidinger, Stephanie Deutscher, Markus Beier, Manfred Gessler, Norbert Graf, Hans-Peter Lenhof, Andreas Keller, Eckart Meese |
Journal | BMC genomics
(BMC Genomics)
Vol. 13
Pg. 379
(Aug 07 2012)
ISSN: 1471-2164 [Electronic] England |
PMID | 22871070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Case-Control Studies
- Child, Preschool
- Cluster Analysis
- Humans
- MicroRNAs
(blood, genetics)
- Transcriptome
(drug effects)
- Wilms Tumor
(blood, drug therapy, genetics)
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