[Clinical effects of budesonide/formoterol combination drug in elder patients with asthma compared with budesonide plus tulobuterol patch combination treatment].

Abstract

BACKGROUND AND AIMS:

Tulobuterol patch (Tulo) is often used for treatment of elder patient with asthma in Japan. However, there is no evidence either ICS plus Tulo or ICS/LABA combination is better for elder patient.

METHODS:

Elder patients with asthma (aged≥ 70, n=17) who had treated with budesonide (BUD) 400 μg/day plus Tulo 2 mg/day, were randomly assigned either to change control medication to budesonide/formoterol combination (BUD/FM) 320/9 μg/day or to keep BUD plus Tulo treatment for 12 weeks.

RESULTS:

At week 4 and week 12, the BUD/FM group showed significant increase in lung function (FEV1, %FEV1) and mini AQLQ score compared with the BUD plus Tulo group. The BUD/FM group also showed decrease in Tumor Necrosis Factor-alpha level in exhaled breath condensate at week 12. No adverse event was observed in both groups.

CONCLUSION:

In elder patients with asthma, treatment with BUD/FM does not have any clinical disadvantage and may provide better efficacy in lung function, QOL, and possibly anti-inflammation compared with BUD plus Tulo treatment.

• Authors: Yojiro Onari, Yoshinori Haruta, Kenichi Mukaida, Keiichi Kondoh
• Journal: Arerugi = [Allergy] (Arerugi) Vol. 61 Issue 6 Pg. 820-31 (Jun 2012) ISSN: 0021-4884 [Print] Japan
• PMID: 22868522 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Bronchodilator Agents
• Ethanolamines
• Tumor Necrosis Factor-alpha
• Budesonide
• tulobuterol
• Terbutaline
• Formoterol Fumarate

Topics

• Aged
• Aged, 80 and over
• Asthma (diagnosis, drug therapy)
• Biomarkers (analysis)
• Breath Tests
• Bronchodilator Agents (administration & dosage)
• Budesonide (administration & dosage)
• Drug Therapy, Combination
• Ethanolamines (administration & dosage)
• Female
• Formoterol Fumarate
• Humans
• Male
• Quality of Life
• Terbutaline (administration & dosage, analogs & derivatives)
• Time Factors
• Transdermal Patch
• Tumor Necrosis Factor-alpha (analysis)