Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.

Abstract

The development of inflammation (experimental model of peritonitis induced by administration of sodium thioglycolate) was accompanied by a decrease in osmotic resistance of erythrocytes. Changes in osmotic resistance of erythrocytes associated with preliminary (15 min before induction of inflammation) administration of peptide Pro-Gly-Pro were significantly weaker, and the percentage of hemolyzed cells was reduced. The peptide injected against the background of developed inflammation (1 h 45 min after induction) had no corrective effect on osmotic resistance. During in vitro experiments, Pro-Gly-Pro did not affect hemolysis of intact erythrocytes. These results support the assumption that prophylactic administration of the peptide protects erythrocyte membranes and increases their osmotic resistance.

• Authors: M G Golubeva, B A Umarova, G N Kopylova, G E Samonina, N S Bondarenko, O V Cheremnova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 3 Pg. 295-7 (Jul 2012) ISSN: 1573-8221 [Electronic] United States
• PMID: 22866294 (Publication Type: Journal Article)

Chemical References

• Oligopeptides
• prolyl-glycyl-proline
• Proline

Topics

• Animals
• Cells, Cultured
• Erythrocytes (drug effects)
• Inflammation (drug therapy)
• Oligopeptides (pharmacology, therapeutic use)
• Osmotic Pressure (drug effects)
• Proline (analogs & derivatives, pharmacology, therapeutic use)
• Rats