Efficacy of quick-release lornoxicam versus placebo for acute pain management after dental implant surgery: a randomised placebo-controlled triple-blind trial.

Abstract

AIM:

To assess the efficacy of quick-release lornoxicam (LNX) on patient-reported acute pain after dental implant surgery.

MATERIALS AND METHODS:

The study included subjects in good general health, aged 18 to 65 and scheduled to receive a maximum of three implants in the same quadrant. Participants received either 8 mg LNX or placebo and were asked to use the medications in case of pain in the first 120 min after implant surgery. Assessment of efficacy was performed using self-assessment questionnaires for the evaluation of pain intensity and pain relief for 12 h post dosing. Patients were also asked to record the rescue analgesic number. Evaluation of patient satisfaction was assessed using a 7-point scale. Safety was evaluated by the incidence of adverse events.

RESULTS:

A total of 83 (LNX/placebo, 42/41) patients who met the inclusion criteria and finished the evaluation period were included in the study. The proportion of patients experiencing postoperative pain was significantly lower in the LNX-treated group compared to the placebo group. Patients in the LNX group reported significantly higher pain relief scores than the placebo group. Twenty-nine patients in the placebo group and 6 patients in the LNX group used rescue analgesics. The number of used rescue analgesics was 1.024 ± 0.79 and 0.167 ± 0.43 in the placebo and LNX groups, respectively. The level of patient satisfaction was significantly higher in the LNX-treated patients (P = 0.007). No adverse events were reported during the study period.

CONCLUSIONS:

Quick-release LNX is effective in postoperative acute pain control and has a high safety profile following dental implant surgery.

• Authors: Nilüfer Bölükbasi, Selim Ersanli, Cansu Basegmez, Tayfun Ozdemir, Süleyman Ozyalcin
• Journal: European journal of oral implantology (Eur J Oral Implantol) Vol. 5 Issue 2 Pg. 165-73 ( 2012) ISSN: 1756-2406 [Print] England
• PMID: 22866292 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piroxicam
• lornoxicam

Topics

• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Chi-Square Distribution
• Dental Implantation, Endosseous (adverse effects)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Pain Measurement
• Pain, Postoperative (drug therapy, etiology)
• Patient Satisfaction
• Piroxicam (administration & dosage, analogs & derivatives, therapeutic use)
• Self Report
• Statistics, Nonparametric