Abstract | AIM: METHODS: Non-diabetic CKD (stages 1-3) patients who underwent renal biopsy were enrolled in this study. Renal arteriolosclerosis was defined by the presence of hyaline changes and vessel wall thickening in the renal biopsy specimens. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in CKD patients. RESULTS: A total of 208 CKD patients (age 36.0±13.6 years; 94 male) who underwent renal biopsy were included. Univariate analysis showed that the serum C3 level was positively correlated with age, body mass index, blood pressure and the serum triglyceride, LDL cholesterol and CRP (p<0.001). The serum C3 level was also inversely correlated with serum HDL cholesterol (p<0.001). Multiple regression analysis identified that the serum C3 (p=0.043) as well as age (p<0.001), serum uric acid (p=0.009) and eGFR (p= 0.025) were independently associated with the severity of renal arteriolosclerosis. CONCLUSION:
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Authors | Chiari Kojima, Takashi Takei, Tetsuya Ogawa, Kosaku Nitta |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 19
Issue 9
Pg. 854-61
( 2012)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 22863782
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Cholesterol, LDL
- Complement C3
- Triglycerides
- C-Reactive Protein
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Topics |
- Adult
- Arteriolosclerosis
(blood, diagnosis, etiology)
- Biomarkers
(blood)
- Blood Pressure
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Cholesterol, LDL
(blood)
- Complement C3
(metabolism)
- Female
- Humans
- Male
- Prognosis
- Renal Insufficiency, Chronic
(blood, complications)
- Risk Factors
- Triglycerides
(blood)
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