[Experimental study on effect of combination of Epimedii Folium/ Ligustri Lucidi Fructus and dexamethasone on asthmatic rats].

Abstract

OBJECTIVE:

To study the anti-inflammatory effect of the combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone on asthma and its effect in inhibiting adverse reaction against hormone.

METHOD:

Dexamethasone had been injected intraperitoneally into asthmatic model rats for 2 weeks, together with the oral administration of Epimedii Folium and Ligustri Lucidi Fructus. The contents of IL-4, INF-gamma, IL-5 and GCR in BALF, serum COR, plasma ACTH and hypothalamic CRH were observed.

RESULT:

The combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone can significantly decrease the contents of IL-5 and IL-4 in BALF and ACTH and CRH content in plasma, increase the content of IFN-gamma and GCR in BALF and balance Th1/Th2.

CONCLUSION:

The combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone has a better anti-inflammatory effect on asthmatic model rats, and play a protective role in the pathway of endogenous dexamethasone.

• Authors: Renhui Liu, Liping Xu, Xiujuan Wang, Jing Yang, Pei Wang, Liang Pan
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 10 Pg. 1497-9 (May 2012) ISSN: 1001-5302 [Print] China
• PMID: 22860470 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Drugs, Chinese Herbal
• epimedii flavone
• Dexamethasone

Topics

• Animals
• Asthma (drug therapy, immunology)
• Bronchoalveolar Lavage Fluid (immunology)
• Cytokines (analysis)
• Dexamethasone (administration & dosage)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (administration & dosage)
• Ligustrum
• Male
• Rats
• Rats, Sprague-Dawley
• Th1 Cells (immunology)
• Th2 Cells (immunology)