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[Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice].

AbstractOBJECTIVE:
To study the effect of Lycium ruthenicum anthocyanins on atherosclerosis (AS) in mice.
METHOD:
Normal mice were taken as the control group, and hyperlipemia mice were divided into the model group, Lycium ruthenicum anthocyanins low, medium and high dose groups, and the simvastatin drug control group. After the oral administration, blood lipid indicators were detected by enzymatic analysis. The histomorphological changes in aortas, hearts and livers were observed, and liver-related indicators were determined by using hematoxylin-eosin (HE) staining.
RESULT:
Compared with the high-fat group, L. ruthenicum anthocyanins low, medium and high dose groups showed significant decrease in total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and atherosclerotic index (AI) (P < 0.05). However, high-density lipoprotein cholesterol (HDL-C) level showed a trend of higher than the model group. Liver's total antioxidant capacity (T-AOC), Glutathione peroxidase (GSH-PX), lipoprotein lipase (LPL) were significantly increased (P < 0.05), malondialdehyde (MDA) was markedly decreased (P < 0.01); the percentage of aortic plaque area of each anthocyanins dose group in the total area was significantly lower than the model group (P < 0.05); severity of aorta, heart and liver were significantly lighter than the high-fat group. But the media dose group was similar with the simvastatin group.
CONCLUSION:
L. ruthenicum anthocyanins can interfere the formation of AS, while lowering blood lipid levels in mice.
AuthorsLi Lin, Jin Li, Haiying Lv, Yuting Ma, Yiping Qian
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 10 Pg. 1460-6 (May 2012) ISSN: 1001-5302 [Print] China
PMID22860462 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthocyanins
  • Lipids
  • Glutathione Peroxidase
Topics
  • Animals
  • Anthocyanins (therapeutic use)
  • Atherosclerosis (prevention & control)
  • Body Weight (drug effects)
  • Glutathione Peroxidase (metabolism)
  • Hypercholesterolemia (blood, drug therapy, pathology)
  • Lipids (blood)
  • Liver (pathology)
  • Lycium (chemistry)
  • Male
  • Mice
  • Phytotherapy

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