Not hysteria: ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis.

Abstract

We report a case of a 33-year-old nulliparous woman who, following a short prodromal illness, experienced a series of psychiatric and behavioural symptoms. These included states of terror, insomnia, delirium, self-harm and suicidal ideation, facial dyskinesias, verbigeration, cognitive impairment, reduced responsiveness, violence and paranoia. A diagnosis of anti-N-methyl-d-aspartate (NMDAR) encephalitis was made 50 days after symptom onset. Early tumour removal is associated with an improved prognosis and a laparoscopic oophorectomy was performed following detection of a dermoid cyst. Within 24 hours of the operation there was marked improvement in cognitive function and appetite.

• Authors: R Roberts, N J J MacDougall, P O'Brien, K Abdelaziz, J Christie, R Swingler
• Journal: Scottish medical journal (Scott Med J) Vol. 57 Issue 3 Pg. 182 (Aug 2012) ISSN: 0036-9330 [Print] Scotland
• PMID: 22859813 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Receptors, N-Methyl-D-Aspartate
• Prednisolone
• Methylprednisolone

Topics

• Adult
• Anti-N-Methyl-D-Aspartate Receptor Encephalitis (diagnosis, drug therapy, surgery)
• Autoantibodies (isolation & purification)
• Cognition Disorders (etiology)
• Dermoid Cyst (complications, diagnosis, surgery)
• Dyskinesias (etiology)
• Female
• Humans
• Laparoscopy
• Methylprednisolone (administration & dosage)
• Ovarian Neoplasms (complications, diagnosis, surgery)
• Ovariectomy (methods)
• Personality Disorders (etiology)
• Prednisolone (administration & dosage)
• Receptors, N-Methyl-D-Aspartate (isolation & purification)
• Sleep Wake Disorders (etiology)
• Treatment Outcome