Are epidemiologic cut-off values predictors of the in vivo efficacy of azoles in experimental aspergillosis?

Abstract

We tried to correlate the in vitro activity and the in vivo efficacy of voriconazole (VRC) and posaconazole (POS) against Aspergillus flavus and Aspergillus niger. The in vitro susceptibility of a large set of isolates was determined by broth microdilution and disk diffusion methods, while the in vivo efficacy was assessed in a murine model of disseminated infection. For A. flavus, VRC showed efficacy even for strains with MICs above the epidemiologic cutoff value (ECV) (1 μg/mL). For A. niger, VRC was ineffective against those strains for which the MIC was 1 dilution below the corresponding ECV (2 μg/mL). POS showed efficacy against all the strains of both species included in the study, although isolates with MICs > ECV were not tested.

• Authors: Enrique Calvo, F Javier Pastor, Deanna A Sutton, Anette W Fothergill, Michael G Rinaldi, Valentina Salas, Josep Guarro
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 74 Issue 2 Pg. 158-65 (Oct 2012) ISSN: 1879-0070 [Electronic] United States
• PMID: 22858549 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• posaconazole
• Voriconazole

Topics

• Animals
• Antifungal Agents (administration & dosage, pharmacology)
• Aspergillosis (drug therapy)
• Aspergillus flavus (drug effects)
• Aspergillus niger (drug effects)
• Disease Models, Animal
• Male
• Mice
• Microbial Sensitivity Tests
• Pyrimidines (administration & dosage, pharmacology)
• Treatment Outcome
• Triazoles (administration & dosage, pharmacology)
• Voriconazole