GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol.

Abstract

OBJECTIVE:

To evaluate, whether Gonadotropin-releasing hormone-agonist (GnRH-agonist or GnRH-ag) trigger in patients undergoing the ultrashort GnRH-ag/GnRH-antagonist (GnRH-ant) protocol is as effective as in patients at high risk to develop severe ovarian hyperstimulation syndrome (OHSS), who undergo the multidose GnRH-ant protocol.

DESIGN:

Cohort study.

SETTING:

University hospital.

PATIENTS:

All consecutive women aged ≤35 years admitted to our IVF unit from January 2011 to October 2011 who reached the ovum pick-up stage.

INTERVENTIONS:

Triggering final oocytes maturation by GnRH-ag instead of hCG, in high-responder patients undergoing either the ultrashort GnRH-ag/GnRH-ant or the multidose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols.

MAIN OUTCOME MEASURES:

Ovarian stimulation characteristics, percentage of mature oocytes, fertilization and pregnancy rates.

RESULTS:

No inbetween groups differences were observed in ovarian-stimulation related variable, percentage of mature oocytes, fertilization or pregnancy rates. No case of moderate-severe OHSS was reported in the study, or the control groups.

CONCLUSIONS:

Three consecutive doses of daily GnRH-ag administration at the beginning of ultrashort flare GnRH-ag/GnRH-ant COH protocol, did not interfere with the ability of the GnRH-ag to trigger final oocytes maturation at the end of the COH cycle.

• Authors: Raoul Orvieto, Ravit Nahum, Efraim Zohav, Gad Liberty, Eyal Y Anteby, Simion Meltcer
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 29 Issue 1 Pg. 51-3 (Jan 2013) ISSN: 1473-0766 [Electronic] England
• PMID: 22857268 (Publication Type: Journal Article)

Chemical References

• Gonadotropins
• Luteolytic Agents
• Triptorelin Pamoate
• Gonadotropin-Releasing Hormone

Topics

• Adult
• Cohort Studies
• Databases, Factual
• Female
• Fertilization (drug effects)
• Fertilization in Vitro (methods)
• Gonadotropin-Releasing Hormone (agonists, antagonists & inhibitors)
• Gonadotropins (administration & dosage)
• Humans
• Infertility, Female (drug therapy, epidemiology)
• Luteolytic Agents (administration & dosage)
• Oocytes (cytology, drug effects)
• Ovarian Hyperstimulation Syndrome (epidemiology, prevention & control)
• Ovulation (drug effects, physiology)
• Ovulation Induction (methods)
• Pregnancy
• Pregnancy Rate
• Risk Factors
• Triptorelin Pamoate (administration & dosage)