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Cardiovascular protection of magnolol: cell-type specificity and dose-related effects.

Abstract
Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mechanisms of magnolol on cardiovascular protection depends on cell types and dosages, and will be reviewed and discussed in this article. Magnolol under low and moderate dosage possesses the ability to protect heart from ischemic/reperfusion injury, reduces atherosclerotic change, protects endothelial cell against apoptosis and inhibits neutrophil-endothelial adhesion. The moderate to high concentration of magnolol mainly acts on smooth muscle cells and platelets. Magnolol induces apoptosis in vascular smooth muscle cells at moderate concentration and inhibits proliferation at moderate and high concentration. High concentration of magnolol also abrogates platelet activation, aggregation and thrombus formation. Magnolol also serves as an smooth muscle relaxant only upon the high concentration. Oral intake of magnolol to reach the therapeutic level for cardiovascular protection is applicable, thus makes magnolol an agent of great potential for preventing cardiovascular diseases in high-risk patients.
AuthorsJennifer Hui-Chun Ho, Chuang-Ye Hong
JournalJournal of biomedical science (J Biomed Sci) Vol. 19 Pg. 70 (Jul 31 2012) ISSN: 1423-0127 [Electronic] England
PMID22849814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biphenyl Compounds
  • Drugs, Chinese Herbal
  • Lignans
  • magnolol
Topics
  • Apoptosis (drug effects)
  • Biphenyl Compounds (chemistry, therapeutic use)
  • Cardiovascular System (drug effects)
  • Drugs, Chinese Herbal (chemistry)
  • Humans
  • Inflammation (prevention & control)
  • Lignans (chemistry, therapeutic use)
  • Magnolia (chemistry)
  • Muscle, Smooth, Vascular (cytology, drug effects)
  • Myocytes, Cardiac (cytology, drug effects)
  • Myocytes, Smooth Muscle (cytology, drug effects)

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