HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer.

AbstractBACKGROUND:
Radiation-induced skin reaction (RISR) is one of the most common and distressing side effects of radiotherapy in patients with cancer. It is featured with swelling, redness, itching, pain, breaks in skin, discomfort, and a burning sensation. There is a lack of convincing evidence supporting any single practice in the prevention or management of RISR.
METHODS/DESIGNS:
This double-blinded randomised controlled trial aims to investigate the effects of a natural oil-based emulsion containing allantoin (as known as Moogoo Udder Cream®) versus aqueous cream in reducing RISR, improving pain, itching and quality of life in this patient group. One group will receive Moogoo Udder Cream®. Another group will receive aqueous cream. Outcome measures will be collected using patient self-administered questionnaire, interviewer administered questionnaire and clinician assessment at commencement of radiotherapy, weekly during radiotherapy, and four weeks after the completion of radiotherapy.
DISCUSSION:
Despite advances of radiologic advances and supportive care, RISR are still not well managed. There is a lack of efficacious interventions in managing RISR. While anecdotal evidence suggests that Moogoo Udder Cream® may be effective in managing RISR, research is needed to substantiate this claim. This paper presents the design of a double blind randomised controlled trial that will evaluate the effects of Moogoo Udder Cream® versus aqueous cream for managing in RISR in patients with cancer.
TRIAL REGISTRATION:
ACTRN 12612000568819.
AuthorsRaymond Javan Chan, Jacqui Keller, Robyn Cheuk, Rae Blades, Lee Tripcony, Samantha Keogh
JournalRadiation oncology (London, England) (Radiat Oncol) Vol. 7 Pg. 121 (Jul 31 2012) ISSN: 1748-717X [Electronic] England
PMID22849762 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Emulsions
  • Oils
  • Allantoin
Topics
  • Allantoin (chemistry, therapeutic use)
  • Breast Neoplasms (radiotherapy)
  • Double-Blind Method
  • Emulsions (therapeutic use)
  • Female
  • Head and Neck Neoplasms (radiotherapy)
  • Humans
  • Lung Neoplasms (radiotherapy)
  • Male
  • Oils (therapeutic use)
  • Radiodermatitis (drug therapy)
  • Radiotherapy (adverse effects)
  • Research Design

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: