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Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics.

Abstract
Down syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years. Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific genes and pathways for rescuing some phenotypes. Recently, progress has been made by characterization of brain alterations in mouse models of Down syndrome. This review will highlight the main molecular and cellular findings recently described for these models, particularly with respect to their relationship to Down syndrome phenotypes.
AuthorsNicole Créau
JournalNeural plasticity (Neural Plast) Vol. 2012 Pg. 171639 ( 2012) ISSN: 1687-5443 [Electronic] United States
PMID22848846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Proteome
Topics
  • Animals
  • Brain (pathology)
  • Disease Models, Animal
  • Down Syndrome (drug therapy, genetics, metabolism, pathology)
  • Humans
  • Metabolic Networks and Pathways (genetics, physiology)
  • Mice
  • Proteome (genetics)
  • Transcriptome (genetics)

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