Abstract |
In a randomized, double-blind clinical trial from general practice, 500 mg metronidazole pessaries applied once daily for seven days were compared with placebo in the treatment of bacterial vaginosis. Seventy-five women completed the study. At the follow-up visit immediately after completion of treatment, none of the patients on metronidazole fulfilled the criteria for bacterial vaginosis, compared with 12 (35%) in the placebo group (p less than 0.001). Nine (22%) of the patients treated with metronidazole harboured Gardnerella vaginalis after treatments, compared with 31 (91%) in the placebo group (p less than 0.001). Symptoms had improved or disappeared in 33 (80%) on metronidazole, and in 18 (53%) on placebo therapy (p less than 0.05). Four weeks after the follow-up visit, symptoms were reported by 28% in the metronidazole group and by 44% in the placebo group (p greater than 0.05). Metronidazole pessaries are effective in the treatment of bacterial vaginosis.
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Authors | F Bro |
Journal | Scandinavian journal of primary health care
(Scand J Prim Health Care)
Vol. 8
Issue 4
Pg. 219-23
(Dec 1990)
ISSN: 0281-3432 [Print] United States |
PMID | 2284521
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Candidiasis, Vulvovaginal
(drug therapy)
- Double-Blind Method
- Family Practice
- Female
- Gardnerella vaginalis
(isolation & purification)
- Haemophilus Infections
(drug therapy, microbiology)
- Humans
- Metronidazole
(administration & dosage, therapeutic use)
- Pessaries
- Placebos
- Vaginitis
(diagnosis, drug therapy)
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