Abstract | BACKGROUND: The natural triterpenes, erythrodiol and uvaol, exert anti-inflammatory, vasorelaxing and anti-proliferative effects. Angiotensin II is a well-known profibrotic and proliferative agent that participates in the cardiac remodeling associated with different pathological situations through the stimulation and proliferation of cardiac fibroblasts. Therefore, the aim of the study was to investigate the preventive effects of the natural triterpenes erythrodiol and uvaol on the proliferation and collagen production induced by angiotensin II in cardiac myofibroblasts. Their actions on cardiac hypertrophy triggered by angiotensin II were also studied. METHODOLOGY/PRINCIPAL FINDINGS: CONCLUSIONS/SIGNIFICANCE:
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Authors | Ruben Martín, Maria Miana, Raquel Jurado-López, Ernesto Martínez-Martínez, Nieves Gómez-Hurtado, Carmen Delgado, Maria Visitación Bartolomé, José Alberto San Román, Claudia Cordova, Vicente Lahera, Maria Luisa Nieto, Victoria Cachofeiro |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 7
Pg. e41545
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22844495
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Triterpenes
- Angiotensin II
- erythrodiol
- Oleanolic Acid
- Collagen
- uvaol
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Topics |
- Angiotensin II
(pharmacology)
- Animals
- Apoptosis
(drug effects)
- Cardiomegaly
(chemically induced, metabolism, pathology, prevention & control)
- Cell Proliferation
(drug effects)
- Collagen
(metabolism)
- Dose-Response Relationship, Drug
- Fibrosis
- Male
- Mice
- Myofibroblasts
(drug effects, metabolism, pathology)
- Oleanolic Acid
(analogs & derivatives, pharmacology)
- Rats
- Triterpenes
(pharmacology)
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