Biochemical failure after carbon ion radiotherapy for prostate cancer.

Abstract

BACKGROUND/AIM:

Biochemical failure after radiotherapy for prostate cancer occurs infrequently, but some cases progress to a poor outcome. The aim of this study was to examine prognosis after biochemical failure.

PATIENTS AND METHODS:

A total of 728 patients were treated with carbon ion radiotherapy, and biochemical failure occurred in 90 (12.4%). Their outcomes were examined according to risk factors, histological findings, and androgen deprivation therapy (ADT).

RESULTS:

Biochemical failure rates were 12%, 6%, and 15% in low-, intermediate- and high-risk patients. Most patients responded favorably to salvage therapy. Some high-risk patients (25%) progressed to poor outcome; half experienced failure after ADT, while the rest during ADT, indicating that ADT had a slight influence. Patients who died from their disease had approximately two years of biochemical failure-free time and three years of survival after failure. Their tumor showed the presence and the increased proportion of histologically high-grade growth patterns.

CONCLUSION:

Histological growth patterns and short biochemical failure-free time are prognostic factors for poor outcome regardless of ADT.

• Authors: Jun Shimazaki, Hiroshi Tsuji, Hitoshi Ishikawa, Tadashi Kamada, Masaoki Harada, Koichiro Akakura, Hiroyoshi Suzuki, Tomohiko Ichikawa, Hirohiko Tsujii
• Journal: Anticancer research (Anticancer Res) Vol. 32 Issue 8 Pg. 3267-73 (Aug 2012) ISSN: 1791-7530 [Electronic] Greece
• PMID: 22843901 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Carbon Radioisotopes

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Agents, Hormonal (therapeutic use)
• Carbon Radioisotopes (therapeutic use)
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (drug therapy, metabolism, radiotherapy)