Abstract | BACKGROUND: METHODS: RESULTS: A total of eight of the 15 AS patients had CRSD (irregular sleep-wake type, n=4; free-running type n=2; delayed sleep phase type, n=2). The nighttime serum melatonin levels of the AS patients were significantly lower than those of the controls at the measured time points during the night. The nocturnal melatonin levels were comparably low both in AS patients with and without CRSD except for the cases with delayed sleep phase type, which showed normal but delayed peak melatonin level. Six out of eight CRSD cases were given a daily dose of 1mg of melatonin between 18:00 and 19:00 regularly for three months. After receiving the treatment, the sleep patterns improved in four cases. CONCLUSION: This study revealed a high prevalence of CRSD in AS patients, which may be related to abnormal serum melatonin profiles.
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Authors | Yoshikazu Takaesu, Yoko Komada, Yuichi Inoue |
Journal | Sleep medicine
(Sleep Med)
Vol. 13
Issue 9
Pg. 1164-70
(Oct 2012)
ISSN: 1878-5506 [Electronic] Netherlands |
PMID | 22841843
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Angelman Syndrome
(blood, complications)
- Case-Control Studies
- Child
- Circadian Rhythm
(physiology)
- Female
- Humans
- Male
- Melatonin
(blood)
- Sleep Disorders, Circadian Rhythm
(blood, complications)
- Young Adult
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