Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.

Abstract

Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.

• Authors: Adam Macneil, Ute Ströher, Eileen Farnon, Shelley Campbell, Deborah Cannon, Christopher D Paddock, Clifton P Drew, Matthew Kuehnert, Barbara Knust, Robert Gruenenfelder, Sherif R Zaki, Pierre E Rollin, Stuart T Nichol, LCMV Transplant Investigation Team
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 18 Issue 8 Pg. 1256-62 (Aug 2012) ISSN: 1080-6059 [Electronic] United States
• PMID: 22839997 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adolescent
• Female
• Humans
• Kidney (pathology, virology)
• Liver (pathology, virology)
• Lung (pathology, virology)
• Lymphocytic Choriomeningitis (diagnosis, mortality, transmission, virology)
• Lymphocytic choriomeningitis virus (genetics, isolation & purification)
• Middle Aged
• Organ Transplantation (adverse effects)
• Reverse Transcriptase Polymerase Chain Reaction
• Tissue Donors
• United States (epidemiology)