[Prognostic significance of platelet metabolism in patients with cerebrovascular complications of hypertension in combination with coronary heart disease].

Abstract

The study of hemostasis and NAD(P)-dependent platelet dehydrogenases activity was made in 90 patients with cerebrovascular complications (development of ischemic stroke) of hypertension and coronary heart disease. On the basis of NADP-dependent platelet dehydrogenases activity we suggested a mode of prognostication a development of repeated cerebrovascular complications of thrombotic nature (the acute stroke, transitory ischemic attack, acute myocardial infarction, cardiovascular death). The proposed prognostic factor has heightened sensibility and specificity.

• Authors: N Iu Shimokhina, A A Savchenko, M M Petrova, D S Kaskaeva
• Journal: Kardiologiia (Kardiologiia) Vol. 52 Issue 6 Pg. 14-8 ( 2012) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 22839664 (Publication Type: English Abstract, Journal Article)

Chemical References

• Glutamate Dehydrogenase (NADP+)

Topics

• Blood Platelets (metabolism)
• Brain Ischemia (diagnosis, enzymology, etiology, physiopathology)
• Female
• Glutamate Dehydrogenase (NADP+) (metabolism)
• Hemostasis
• Humans
• Hypertension (complications)
• Male
• Middle Aged
• Monitoring, Physiologic (methods)
• Myocardial Ischemia (complications)
• Platelet Function Tests (methods)
• Predictive Value of Tests
• Prognosis
• Secondary Prevention