Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.

Abstract

Scleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc.

• Authors: Takahiro Nunokawa, Masanobu Akazawa, Naoto Yokogawa, Kota Shimada, Kazuko Hiramatsu, Yasuhide Nishio, Shoji Sugii
• Journal: American journal of therapeutics (Am J Ther) 2014 Sep-Oct Vol. 21 Issue 5 Pg. e130-3 ISSN: 1536-3686 [Electronic] United States
• PMID: 22836123 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisolone
• Tacrolimus

Topics

• Acute Kidney Injury (chemically induced)
• Aged
• Female
• Humans
• Prednisolone (adverse effects)
• Scleroderma, Systemic (complications)
• Tacrolimus (adverse effects)
• Thrombotic Microangiopathies (chemically induced)