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Controversies about the chromosomal stability of cultivated mesenchymal stem cells: their clinical use is it safe?

Abstract
The usefulness of adult stem cells in research and therapeutic applications highly relies on their genomic integrity and stability. Many laboratories including ours have addressed this concern using methods such as karyotyping, Qbanding, fluorescent in situ hybridization, array CGH, flow cytometry and Pap test to evaluate number and structure of chromosomes and cellular phenotype. This review attempts to summarize the findings reported so far for the studies on chromosomal aberrations in adult stem cells and warrant to perform certain basic tests before transplantation to avoid any adverse reactions, which will thus aid in better therapeutic output after cellular transplantation in the treatment of various diseases.
AuthorsReginaldo Justino Ferreira, Ana Carolina Irioda, Ricardo Correa Cunha, Julio Cesarm Francisco, Luiz Cesar Guarita-Souza, Garikipati Venkata Naga Srikanth, Soniya Nityanand, Roberto Rosati, Juan Carlos Chachques, Katherine Athayde Teixeira de Carvalho
JournalCurrent stem cell research & therapy (Curr Stem Cell Res Ther) Vol. 7 Issue 5 Pg. 356-63 (Sep 2012) ISSN: 2212-3946 [Electronic] United Arab Emirates
PMID22834994 (Publication Type: Journal Article, Review)
Topics
  • Adult Stem Cells (cytology, metabolism)
  • Animals
  • Cell Culture Techniques
  • Chromosomal Instability
  • Chromosome Aberrations
  • Genetic Testing
  • Humans
  • Mesenchymal Stem Cell Transplantation (methods)
  • Mesenchymal Stem Cells (cytology, metabolism)
  • Regenerative Medicine

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