Polymer nanoparticles--a novel strategy for administration of Paclitaxel in cancer chemotherapy.

Abstract

The main challenge encountered while treating using Paclitaxel (PTX) is its poor solubility in aqueous solutions. The cremophor used in the formulation can cause various side effects such as hypersensitivity, myelosuppression and neurotoxicity and also leads to non-specific distribution in tumor and normal tissues. Since the structure of Paclitaxel does not possess a functional group, it is not easy to manipulate to enhance the solubility. Such limitations can be overcome by delivering Paclitaxel with the aid of drug delivery systems such as polymeric micelles, nanoparticles, hydrogels and liposomes. The review discusses various approaches of Paclitaxel delivery via polymeric nanoparticles. It focuses on the passive and active targeting of Paclitaxel.

• Authors: G Deepa, N Ashwanikumar, J J Pillai, G S V Kumar
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 19 Issue 36 Pg. 6207-13 ( 2012) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 22834822 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies
• Antineoplastic Agents, Phytogenic
• Aptamers, Nucleotide
• Drug Carriers
• Peptides
• Polymers
• Folic Acid
• Receptors, Vascular Endothelial Growth Factor
• Paclitaxel

Topics

• Antibodies (immunology)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Aptamers, Nucleotide (chemistry, metabolism)
• Drug Carriers (chemistry)
• Folic Acid (chemistry, metabolism)
• Humans
• Hydrogen-Ion Concentration
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Paclitaxel (administration & dosage)
• Peptides (chemistry, metabolism)
• Polymers (chemistry)
• Receptors, Vascular Endothelial Growth Factor (metabolism)