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Rasagiline: a guide to its use in Parkinson's disease.

Abstract
Oral rasagiline (Azilect®) as monotherapy or as an adjunct to levodopa provides a useful option in the symptomatic treatment of adult patients with Parkinson's disease. In patients with early Parkinson's disease, monotherapy with rasagiline 1 mg/day improved symptoms of the disease relative to placebo. As adjunctive therapy to levodopa in patients with advanced Parkinson's disease, rasagiline 0.5 or 1 mg/day significantly reduces the total daily 'off' time. Rasagiline is generally well tolerated when administered as monotherapy or as adjunctive therapy.
AuthorsGillian M Keating, Katherine A Lyseng-Williamson, Sheridan M Hoy
JournalCNS drugs (CNS Drugs) Vol. 26 Issue 9 Pg. 781-5 (Sep 1 2012) ISSN: 1172-7047 [Print] New Zealand
PMID22834567 (Publication Type: Journal Article)
Chemical References
  • Antiparkinson Agents
  • Indans
  • Monoamine Oxidase Inhibitors
  • rasagiline
  • Levodopa
  • Dopamine
Topics
  • Administration, Oral
  • Antiparkinson Agents (administration & dosage, adverse effects, therapeutic use)
  • Dopamine (metabolism)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Humans
  • Indans (administration & dosage, adverse effects, therapeutic use)
  • Levodopa (administration & dosage, adverse effects, therapeutic use)
  • Monoamine Oxidase Inhibitors (administration & dosage, adverse effects, therapeutic use)
  • Parkinson Disease (drug therapy, enzymology)
  • Practice Guidelines as Topic
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

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