[Toxicological and sanitary characteristics of fullerene C60 administered to the rat gastrointestinal tract].

Abstract

A four-week experiment dealing with the intragastric administration of fullerene C60 dispersion to rats has established that this substance in a dose of 1 to 10 mg/kg body weight causes a number of changes in the parameters of animals, such as reductions in relative liver weight and isoform CYP 1A2 activity and increases in glutathione reductase activity, eosinophils, and neutrophils. It is concluded that fullerene can affect the animals when orally given in the doses studied.

• Authors: V A Shipelin, E A Arianova, E N Trushina, L I Avren'eva, S Iu Batishcheva, A V Cherkashin, S Kh Soto, N V Lashneva, I V Gmoshinskiĭ, S A Khotimchenko
• Journal: Gigiena i sanitariia (Gig Sanit) 2012 Mar-Apr Issue 2 Pg. 90-4 ISSN: 0016-9900 [Print] Russia (Federation)
• PMID: 22834278 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fullerenes
• Lipid Peroxides
• Cytochrome P-450 Enzyme System
• Glucuronosyltransferase
• Glutathione Transferase
• fullerene C60

Topics

• Administration, Oral
• Animals
• Cytochrome P-450 Enzyme System (metabolism)
• Erythrocyte Count
• Erythrocytes (cytology, drug effects, metabolism)
• Fullerenes (chemistry, pharmacokinetics, toxicity)
• Gastrointestinal Tract (drug effects, metabolism)
• Glucuronosyltransferase (metabolism)
• Glutathione Transferase (metabolism)
• Hygiene
• Intestinal Absorption
• Leukocyte Count
• Lipid Peroxidation (drug effects)
• Lipid Peroxides (blood)
• Male
• Nanoparticles
• Rats
• Rats, Wistar
• Solubility
• Toxicity Tests, Subchronic
• Toxicology