[High-density lipoproteins as a form of daunorubicin transport in hepatoma cells of mice].

Abstract

The efficiency of using high-density lipoproteins (HDLPs) as the transport form of an antineoplastic drug daunorubicin (rubomycin hydrochloride, daunoxome) has been shown on the culture of HA-1 hepatoma cells of mice. The use of HDLPs in a complex with daunorubicin led to an increase in the efficiency of drug transport and cytotoxic action with respect to tumor cells in comparison with hepatocytes of healthy animals.

• Authors: D V Sumenkova, L M Poliakov, L E Panin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 5 Pg. 32-4 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22834127 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Drug Carriers
• Lipoproteins, HDL
• Daunorubicin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics)
• Biological Transport
• Cell Line, Tumor
• Daunorubicin (administration & dosage, pharmacokinetics)
• Drug Carriers (chemistry, pharmacokinetics)
• Lipoproteins, HDL (chemistry, metabolism)
• Mice
• Neoplasms (metabolism)
• Rats