[Estimation of the hypoglycemic effect of phytoecdysteroids].

Abstract

A series of phytoecodysteroids, including alpha-ecdysone, 2-deoxy-alpha-ecdysone, and 2-deoxyecdysterone isolated from Silene praemixta, integristerone A and ecdysterone isolated from Rhaponticum carthamoides and 22-acetylcyasterone and turkesterone isolated from Ajuga turkestanica, exhibit a pronounced hypoglycemic effect in experiments on intact male rats. The most active compounds--ecdysteron and turkesterone--also produce an expressed hypoglycemic effect in animals with model hyperglycemia induced by the administration of glucose, adrenalin and alloxan. Phytoecdysteroids are substances possessing protein-anabolic activity and are somewhat similar to steranobols in this aspect. Phytoecdysteroids exhibit unidirectional effect and are well comparable with steranabol actionon the carbohydrate metabolism.

• Authors: V N Syrov, N Kh Iuldasheva, F R Égamova, G I Ismailova, N D Abdullaev, Z A Khushbaktova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 5 Pg. 28-31 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22834126 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Glucose
• Ecdysteroids
• Hypoglycemic Agents
• Phytosterols
• Ecdysterone
• turkesterone
• Methandrostenolone

Topics

• Ajuga (chemistry)
• Animals
• Asteraceae (chemistry)
• Blood Glucose (drug effects, metabolism)
• Caryophyllaceae (chemistry)
• Ecdysteroids (chemistry, pharmacology)
• Ecdysterone (analogs & derivatives, chemistry, pharmacology)
• Hyperglycemia (drug therapy)
• Hypoglycemic Agents (chemistry, pharmacology)
• Male
• Methandrostenolone (chemistry, pharmacology)
• Phytosterols (chemistry, pharmacology)
• Rats