Elevation of tau protein levels in the cerebrospinal fluid of children with West syndrome.
|
| Abstract | PURPOSE:
West syndrome is an epileptic encephalopathy with a poor developmental outcome. Tau protein levels in the cerebrospinal fluid (CSF) are reported to be markers of axonal damage and neurodegeneration. This study aimed to investigate axonal damage and the effects of adrenocorticotropic hormone (ACTH) therapy on axons in West syndrome, as measured by tau protein levels in CSF. METHODS:
Tau protein levels in CSF before and after ACTH therapy were determined by an enzyme-linked immunosorbent assay in 26 children with West syndrome. Of these 26 children, 18 were symptomatic, and 8 had a cryptogenic form of West syndrome. A group of 41 unaffected children was included in the study as a control group. RESULTS: The levels of tau protein in CSF were significantly higher in children with West syndrome than in the control group, and these levels remained high after ACTH therapy. ACTH therapy was effective for 20 of the 26 children with West syndrome, and their CSF tau protein levels were significantly higher after ACTH therapy than before therapy. CONCLUSION: Our results suggest that axonal damage occurs in West syndrome, as judged by tau protein levels in CSF.
|
|---|---|
| Authors | Hirofumi Inoue, Takeshi Matsushige, Shunji Hasegawa, Arisa Abe, Yasunori Iida, Teruaki Inoue, Takashi Ichiyama |
| Journal | Epilepsy research (Epilepsy Res) Vol. 102 Issue 1-2 Pg. 8-12 (Nov 2012) ISSN: 1872-6844 [Electronic] Netherlands |
| PMID | 22831649 (Publication Type: Journal Article, Review) |
| Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!