Abstract | INTRODUCTION: MATERIALS AND METHODS: Twenty-eight patients with ALL and thirty healthy controls were enrolled to the study. Thirteen patients with ALL were found to have malnutrition. While neutrophil OBF of ALL patients without malnutrition were studied both before induction chemotherapy and 3 months after, the same functions in ALL patients with malnutrition were studied both before induction chemotherapy and when the nutritional status improved. Control group were studied at admission and 3 months later. RESULTS: The OBF of ALL patients with and without malnutrition before induction chemotherapy were found to be significantly lower than the control group (P = 0.009), whereas the OBF were found to be similar in both patient groups with ALL (P = 0.27). The median infection episode rate and the duration of antibiotics therapy during the study period were similar in both patient groups with ALL. The repeated OBF of both patient groups with ALL were shown to increase to similar values with the control group in the third month of chemotherapy (P = 0.002). The median infection episode rate during the first month of chemotherapy was shown to decrease significantly during the third month of chemotherapy in both patient with ALL groups (P < 0.001). CONCLUSIONS: We have not been able to demonstrate an overt effect of malnutrition on OBF. However, our results still need to be verified via further larger scaled studies of OBF in leukemic children with and without malnutrition.
|
Authors | F B Cakir, G Aydogan, C Timur, C Canpolat, A Tulunay, E Eksioglu Demiralp, S G Berrak |
Journal | International journal of laboratory hematology
(Int J Lab Hematol)
Vol. 34
Issue 6
Pg. 648-54
(Dec 2012)
ISSN: 1751-553X [Electronic] England |
PMID | 22830439
(Publication Type: Journal Article)
|
Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Anti-Bacterial Agents
- Tetradecanoylphorbol Acetate
|
Topics |
- Adolescent
- Anti-Bacterial Agents
(pharmacology)
- Child
- Child, Preschool
- Escherichia coli
(physiology)
- Escherichia coli Infections
(physiopathology)
- Female
- Host-Pathogen Interactions
- Humans
- Induction Chemotherapy
- Male
- Malnutrition
(physiopathology)
- Neutrophils
(drug effects, metabolism, microbiology)
- Nutritional Status
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(blood, drug therapy, physiopathology)
- Respiratory Burst
- Tetradecanoylphorbol Acetate
(pharmacology)
- Time Factors
- Treatment Outcome
|