A functional +61G/A polymorphism in epidermal growth factor is associated with glioma risk among Asians.

Abstract

BACKGROUND:

Epidermal growth factor (EGF), a potent mitogenic protein, plays an important role in the development of cancers, including glioma. Previous studies showed that the EGF +61G/A polymorphism (rs4444903) may lead to an alteration in EGF production and/or activity, which can result in individual susceptibility to glioma. However, published data regarding the association between the +61G/A polymorphism and glioma risk was contradictory.

OBJECTIVE:

The aim of this study was to perform a meta-analysis of eligible studies to derive precise estimation of the association of EGF +61G/A with glioma risk.

METHODS:

We performed a pooled analysis of seven published studies that included 1,613 glioma cases and 2,267 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively.

RESULTS:

Overall, no significant associations between the EGF +61G/A polymorphism and glioma cancer risk were found for AA versus GG (OR=0.95, 95% CI=0.62-1.45), GA versus GG (OR=0.94, 95% CI=0.72-1.22), AA/GA versus GG (OR=0.93, 95% CI=0.70-1.23), and AA versus GA/GG (OR=1.04, 95% CI=0.77-1.39). However, in the stratified analysis by ethnicity, the EGF +61G/A polymorphism had a higher risk of glioma development among Asians, but a lower risk among Caucasians.

CONCLUSIONS:

Taken together, the results suggest that the EGF +61G/A polymorphism may contribute to the susceptibility of glioma in different ethnic groups.

• Authors: Xin Xu, Lei Xi, Jie Zeng, Qinhong Yao
• Journal: PloS one (PLoS One) Vol. 7 Issue 7 Pg. e41470 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 22829952 (Publication Type: Journal Article)

Chemical References

• Epidermal Growth Factor

Topics

• Asian People (genetics)
• Epidermal Growth Factor (genetics)
• Female
• Genetic Predisposition to Disease (genetics)
• Glioma (genetics)
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)