Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Data were analyzed from a South Korean occupational cohort of 10,153 people who all received ultrasound measurements of fatty liver and a cardiac computed tomography CAC score. IR was defined by homeostasis model assessment of IR (HOMA-IR) ≥75th percentile. Odds ratios ( ORs) (95% CIs) for the presence of a CAC score >0 were estimated using logistic regression. RESULTS: There were 915 people with a CAC score >0. MetS features were increased ( glucose, blood pressure, triglyceride, and waist) or decreased (HDL-C) among people with a CAC score >0 (all comparisons against CAC score ≤0; P < 0.0001). Of subjects with a CAC score >0, 55% had fatty liver and 33.7% were insulin resistant. Fatty liver (OR 1.21 [95% CI 1.01-1.45]; P = 0.04) and HOMA-IR (1.10 [1.02-1.18]; P = 0.02) were associated with CAC score >0, independently of all MetS features, conventional cardiovascular risk factors, and prior evidence of CVD. The presence of IR and fatty liver combined was associated with CAC score >0 (1.53 [1.20-1.95]; P = 0.001). CONCLUSIONS:
Fatty liver and HOMA-IR are both associated with a CAC score >0 (independently of each other), features of MetS, conventional cardiovascular risk factors, and existing CVD.
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Authors | Ki-Chul Sung, Sarah H Wild, Hyon Joo Kwag, Christopher D Byrne |
Journal | Diabetes care
(Diabetes Care)
Vol. 35
Issue 11
Pg. 2359-64
(Nov 2012)
ISSN: 1935-5548 [Electronic] United States |
PMID | 22829522
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Atherosclerosis
(etiology, metabolism)
- Calcium
(metabolism)
- Fatty Liver
(complications, metabolism)
- Female
- Humans
- Insulin Resistance
(physiology)
- Male
- Metabolic Syndrome
(complications, metabolism)
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Risk Factors
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