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Contact allergy to sorbitans: a follow-up study.

AbstractBACKGROUND:
Sorbitan sesquioleate (SSO), an emulsifier in many corticosteroids, was previously found positive in 8.9% of 112 dermatitis patients.
OBJECTIVE:
The objective of this study was to present data on 24 of 591 dermatitis patients with reactions to SSO and/or sorbitan monooleate (SMO) on patch testing.
METHODS:
A retrospective chart review was conducted on 591 consecutive dermatitis patients patch tested from November 2008 to May 2010. In addition to being tested to a modified North American Contact Dermatitis Group standard series, all patients were tested to a cosmetic series.
RESULTS:
Of the 591 patients tested, 24 reacted to SSO and/or SMO (4.1%), 19 (3.2%) reacted to SSO alone, 1 (0.17%) to SMO alone, and 4 (0.68%) reacted to both. Of the 24 sorbitan-allergic patients, 2 (8.3%) reacted to any of 4 corticosteroid screening chemicals tested.
CONCLUSIONS:
In this follow-up study, 4.1% of 591 dermatitis patients reacted to SSO and/or SMO. Given the presence of SSO in many popular topical corticosteroid formulations, clinicians should consider allergy to sorbitans when patients do not improve with topical corticosteroid therapy.
AuthorsBrienne D Cressey, Neal Kumar, Pamela L Scheinman
JournalDermatitis : contact, atopic, occupational, drug (Dermatitis) 2012 Jul-Aug Vol. 23 Issue 4 Pg. 158-61 ISSN: 2162-5220 [Electronic] United States
PMID22828254 (Publication Type: Journal Article)
Chemical References
  • Cosmetics
  • Glucocorticoids
  • Hexoses
  • Surface-Active Agents
  • sorbitan monooleate
  • sorbitan sesquioleate
Topics
  • Adolescent
  • Adult
  • Child
  • Cosmetics (adverse effects)
  • Dermatitis, Allergic Contact (etiology, immunology)
  • Female
  • Follow-Up Studies
  • Glucocorticoids (adverse effects, immunology)
  • Hexoses (adverse effects, immunology)
  • Humans
  • Male
  • Patch Tests (methods)
  • Surface-Active Agents (adverse effects)
  • Young Adult

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