Abstract | OBJECTIVES: DESIGN AND METHODS: The study involved 315 consecutive outpatients in our hospital (218 males and 97 females) with a mean age of 62.0 ± 9.2. We examined which anthropometric, metabolic and inflammatory variables, including serum levels of pigment epithelium-derived factor (PEDF), a novel marker of insulin resistance were independently associated with fasting apoB48. Moreover, we investigated whether fasting apoB48 levels were correlated with atherosclerotic plaque inflammation evaluated by [(18)F]-fluorodeoxyglucose positron emission tomography (FDG-PET). Carotid [(18)F]-FDG uptake, an index of vascular inflammation within the atherosclerotic plaques, was measured as blood-normalized standardized uptake value, known as the target-to-background ratio (TBR). RESULTS: Mean serum levels of apoB48, PEDF, carotid IMT and TBR values were 2.77 ± 0.21 μg/mL, 13.45 ± 1.03 μg/mL, 0.71 ± 0.15 mm, and 1.43 ± 0.21, respectively. Univariate analysis revealed that apoB48 levels were weakly, but not significantly associated with TBR (p=0.057). In multiple stepwise regression analysis, triglycerides (p<0.001), male (p=0.039), age (inversely, p=0.010), uric acid (p=0.007), medication for diabetes (p=0.029), and PEDF (p=0.049) were independently correlated to fasting apoB48 levels (R(2)=0.371). CONCLUSIONS: The present study reveals that serum levels of PEDF are independently associated with fasting apoB48 levels, suggesting that PEDF level is a novel biomarker that could reflect postprandial hyperlipidemia in humans.
|
Authors | Nobuhiro Tahara, Sho-ichi Yamagishi, Atsuko Tahara, Masayoshi Takeuchi, Tsutomu Imaizumi |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 45
Issue 16-17
Pg. 1404-8
(Nov 2012)
ISSN: 1873-2933 [Electronic] United States |
PMID | 22827961
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoprotein B-48
- Biomarkers
- Eye Proteins
- Glycation End Products, Advanced
- Nerve Growth Factors
- Radiopharmaceuticals
- Serpins
- pigment epithelium-derived factor
- Fluorodeoxyglucose F18
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Apolipoprotein B-48
(blood)
- Biomarkers
(blood)
- Carotid Artery Diseases
(blood, diagnostic imaging)
- Carotid Intima-Media Thickness
- Eye Proteins
(blood)
- Fasting
(blood)
- Female
- Fluorodeoxyglucose F18
- Glycation End Products, Advanced
(blood)
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Nerve Growth Factors
(blood)
- Plaque, Atherosclerotic
(blood, diagnostic imaging)
- Positron-Emission Tomography
- Radiopharmaceuticals
- Regression Analysis
- Serpins
(blood)
|