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Reduction of urinary bile alcohol excretion and serum cholestanol in patients with cerebrotendinous xanthomatosis after oral administration of deoxycholic acid.

Abstract
Deoxycholic acid and chenodeoxycholic acid were administered alternately to four patients with cerebrotendinous xanthomatosis. During this oral therapy serum cholestanol and urinary bile alcohols were determined. Both showed a marked decrease after the start of the two different therapies. It can be concluded that not only chenodeoxycholic acid but also deoxycholic acid is able to suppress endogenous human bile acid synthesis, which is in accordance with other experiments describing the effect of feeding of various bile acids on endogenous bile acid synthesis.
AuthorsB G Wolthers, J C van der Molen, H Walrecht, L F Hesselmans
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 193 Issue 3 Pg. 113-8 (Dec 14 1990) ISSN: 0009-8981 [Print] Netherlands
PMID2282689 (Publication Type: Journal Article)
Chemical References
  • Bile Acids and Salts
  • Cholestanols
  • Deoxycholic Acid
  • Cholestanol
Topics
  • Adult
  • Bile Acids and Salts (biosynthesis)
  • Cholestanol (blood)
  • Cholestanols (urine)
  • Deoxycholic Acid (therapeutic use)
  • Female
  • Humans
  • Lipid Metabolism, Inborn Errors (drug therapy, metabolism)
  • Male
  • Middle Aged
  • Xanthomatosis (drug therapy, metabolism)

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