Intrarenal oxygenation by blood oxygenation level-dependent MRI in contrast nephropathy model: effect of the viscosity and dose.

Abstract

PURPOSE:

To compare the effects of osmolality versus viscosity of radio-contrast media on intra-renal oxygenation as determined by blood oxygenation level-dependent (BOLD) MRI in a model of contrast induced nephropathy (CIN).

MATERIALS AND METHODS:

Twenty-four Sprague-Dawley rats were divided into five groups. Nitric oxide synthase inhibitor L-NAME (10 mg/kg), cyclooxygenase inhibitor indomethacin (10 mg/kg), or saline, and radio-contrast iodixanol (high viscosity, 784 or 1600 mg I/kg) or iothalamate (high osmolality, 1600 mg I/kg) were administered. BOLD MRI images were acquired on Siemens 3 Tesla (T) scanner using a multiple gradient recalled echo sequence at baseline, following L-NAME (or saline), indomethacin (or saline), and radio-contrast agents. R2* (=1/T2*) was used as the BOLD MRI parameter in renal medulla and cortex. Mixed-effects models with first order auto-regressive variance-covariance models were used to analyze the data.

RESULTS:

The magnitude of change in medullary R2* (MR2*) with same dose of iodine was larger with iodixanol compared with iothalalmate both in pretreated groups (303% versus 225.6%, < 0.01) and the control group (191.6% versus -1.8%, P < 0.01). The MR2* change in high dose iodixanol was approximately twice compared with the low dose (303% versus 133%, P < 0.01).

CONCLUSION:

The viscosity of radio-contrast seems to play a more significant role than osmolality in terms of renal oxygenation changes as evaluated by BOLD MRI. Additionally, iodixanol induced a dose-dependent increase in renal medullary hypoxia.

• Authors: Lu-Ping Li, Tammy Franklin, Hongyan Du, Maria Papadopoulou-Rosenzweig, Joann Carbray, Richard Solomon, Pottumarthi V Prasad
• Journal: Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 36 Issue 5 Pg. 1162-7 (Nov 2012) ISSN: 1522-2586 [Electronic] United States
• PMID: 22826125 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Contrast Media
• Triiodobenzoic Acids
• iodixanol
• Oxygen

Topics

• Animals
• Contrast Media (adverse effects, chemistry)
• Dose-Response Relationship, Drug
• Kidney Diseases (blood, chemically induced, diagnosis)
• Magnetic Resonance Imaging
• Male
• Osmolar Concentration
• Oxygen
• Oxygen Consumption
• Rats
• Rats, Sprague-Dawley
• Triiodobenzoic Acids (adverse effects, chemistry)
• Viscosity